The Case against Calcium-Based Phosphate Binders
نویسندگان
چکیده
منابع مشابه
Calcium-based phosphate binders are appropriate in chronic renal failure.
Many nephrologists feel threatened by the allegation that, in patients with chronic renal failure, treatment with calcium-based phosphate binders (calcium acetate and calcium carbonate) may induce coronary artery and cardiac calcification, thereby imposing a greater risk for death compared with sevelamer, a non-calcium-based binder. Acknowledging that drug manufacturers are not unaware of the m...
متن کاملThe effects of non-calcium-based phosphate binders versus calcium-based phosphate binders on cardiovascular calcification and bone remodeling among dialysis patients: a meta-analysis of randomized trials.
BACKGROUND Vascular calcification significantly increases the rates of cardiovascular mortality in hemodialysis (HD) patients. Abnormalities in mineral metabolism may play a role in the pathogenesis of arterial calcification. Whether patients treated with non-calcium-based phosphate binders had reduced aortic vascular calcification compared to those treated with calcium-based phosphate binders ...
متن کاملIron-based phosphate binders: do they offer advantages over currently available phosphate binders?
Increased cardiovascular morbidity and mortality has been associated with the hyperphosphatemia seen in patients with end-stage chronic kidney disease (CKD). Oral phosphate binders are prescribed in these patients to prevent intestinal absorption of dietary phosphate and reduce serum phosphate. In prospective observational cohorts they have shown to decrease all-cause and cardiovascular mortali...
متن کاملDifferences in gastrointestinal calcium absorption after the ingestion of calcium-free phosphate binders.
Both calcium-containing and noncalcium-containing phosphate binders can increase gastrointestinal calcium absorption. Previously, we observed that lanthanum carbonate administration to rats with renal failure is not associated with increased calciuria. Additionally, lanthanum carbonate treatment in dialysis patients has been associated with a less pronounced initial decrease in serum parathyroi...
متن کاملCALCIUM PHOSPHATE CEMENT: STUDY OF (BETA-TRICALCIUM PHOSPHATE, DICALCIUM PHOSPHATE AND CALCIUM CARBONATE SYSTEM
Calcium phosphate cements (CPCs), using B-tricalcium phosphate (ß-TCP, Ca3 (P04)2), dicalcium phosphate (DCP, CaHP04), calcium carbonate (Ca CO3), and hydroxylapatite (HAp, Ca10(P04)6(OH)2) as powder cement and disodium hydrogen phosphate (Na2HP04) solution as liquid component were prepared. After mixing the powder and liquid constituents, injectable and self-setting calcium phosphate cements (...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2006
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.00560206